Binary pan-cancer classes with distinct
WebJun 21, 2024 · The binary cancer groups exhibit distinct YAP-dependent adhesive behavior, and pharmaceutical vulnerabilities, underscoring clinical relevance. … WebBinary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/ TEAD activity Graphical abstract Highlights d YAP/TAZ silencing in multiple …
Binary pan-cancer classes with distinct
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WebAug 1, 2024 · Here, we define pan-cancer binary classes based on distinct expression of YAP and YAP-responsive adhesion regulators. Combining informatics with in vivo and in vitro gain- and loss-of-function studies across multiple murine and human tumor types, we show that opposite pro- or anti-cancer YAP activity functionally defines binary YAP or … WebThe binary cancer groups exhibit distinct YAP-dependent adhesive behavior and pharmaceutical vulnerabilities, underscoring clinical relevance. Mechanistically, distinct …
WebAug 9, 2024 · Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity. Joel D. Pearson, Katherine Huang, Marek Pacal, Sean R. McCurdy, ... Rod Bremner. Pages 1115-1134.e12 Download PDF. Article preview. WebThe demonstration that cancers can be functionally stratified into binary YAP on /YAP off superclasses with distinct therapeutic and genetic vulnerabilities opens a new view on …
WebHere, we define pan-cancer binary classes based on distinct expression of YAP and YAP-responsive adhesion regulators. Combining informatics with in vivo and in vitro gain- and loss-of-function studies across multiple murine and human tumor types, we show that opposite pro- or anti-cancer YAP activity functionally defines binary YAPon or YAPoff ... WebJul 8, 2024 · Small-cell neuroendocrine cancers (SCNCs) are an aggressive cancer subtype. Transdifferentiation toward an SCN phenotype has been reported as a resistance route in response to targeted therapies. Here, we identified a convergence to an SCN state that is widespread across epithelial cancers and is as …
WebFigure 1. Features and mechanisms underlying binary YAP on and YAP off cancer superclasses. (a) Features of YAP/TAZ-deficient (YAP off) and YAP/TAZ-positive (YAP on) cancer classes, including the types, genetic and phenotypic characteristics, and key vulnerabilities.(b) Opposite anti- versus pro-oncogenic YAP/TEAD functions in YAP off … inclusieve sportWebSep 22, 2024 · Cancer heterogeneity impacts therapeutic response, driving efforts to discover over-arching rules that supersede variability. Here, we define pan-cancer binary classes based on distinct expression of YAP and YAP-responsive adhesion regulators. Combining informatics with in vivo and in vitro gain-and loss-of-function studies across … incanto wikiWebAug 9, 2024 · The binary cancer groups exhibit distinct YAP-dependent adhesive behavior and pharmaceutical vulnerabilities, underscoring clinical relevance. Mechanistically, … incanto wharf dcWebOur current primary focus is on cancer lineage plasticity, a phenomenon whereby cancer cells reprogram themselves to an alternative lineage or phenotypic state in order to adapt to selective pressures. ... Wikenheiser-Brokamp, K.A., Knudsen, E.S., Witkiewicz, A.K., Wrana, J.L., Goodrich, D.W., Bremner, R. Binary pan-cancer classes with distinct ... inclusif en arabeWebAug 9, 2024 · Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity. Pearson JD et al. Cancer Cell. 2024 08 09; 39 (8):1115 … incanto wine at trader joe\u0027sWebHome: Cell Press inclusieve technologieWebFigure 1. Features and mechanisms underlying binary YAPon and YAPoff cancer superclasses. (a) Features of YAP/TAZ-deficient (YAPoff) and YAP/TAZ-positive … incanto wine \\u0026 spirits