Cisplatin and apoptosis

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August undefined, 2024

WebThe cardiotoxic effect of chemotherapeutic agents as cisplatin has become a major issue recently. Interference with mitochondrial dynamics, biogenesis, redox status, and … WebMar 15, 2024 · Cell viability and proliferation were detected by counting kit 8 (CCK-8) and 5-ethynyl-2'-deoxyuridine (EdU) assays respectively. Apoptosis and cell cycle were analyzed by flow cytometry. The results indicated that URI knockdown increased the sensitivity of cells to cisplatin by inhibiting proliferation and promoting apoptosis.

IJMS Free Full-Text Multifaceted Mechanisms of Cisplatin …

WebSynergistic killing of lung cancer cells by cisplatin and radiation via autophagy and apoptosis Synergistic killing of lung cancer cells by cisplatin and radiation via autophagy and apoptosis Authors Min Liu 1 , Shumei Ma 2 , Mingbo Liu 2 , Yufei Hou 2 , Bing Liang 2 , Xu Su 3 , Xiaodong Liu 4 Affiliations WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 … side effects of saint john\u0027s wort

Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies ...

WebFeb 13, 2024 · Cisplatin, as the first-line anti-tumor agent, is widely used for treatment of a variety of malignancies including non-small cell lung cancer (NSCLC). However, the acquired resistance has been a major obstacle for the clinical application. WebMar 15, 2013 · The antineoplastic agent cis-diammineplatinum (II) dichloride (cisplatin, CDDP) is part of the poorly effective standard treatment of non-small cell lung carcinoma (NSCLC). Here, we report a novel strategy to improve the efficacy of CDDP. WebMechanisms of Cisplatin-Induced Apoptosis and of Cisplatin Sensitivity: Potential of BIN1 to Act as a Potent Predictor of Cisplatin Sensitivity in Gastric Cancer Treatment Cisplatin is … side effects of sage tea

LncRNA UCA1 Enhances Cisplatin Resistance by Regulating …

Mechanisms of Cisplatin-Induced Acute Kidney Injury: …

WebIn summary, a growing body of evidence suggests that cisplatin-induced cell death does not always come from "classic"apoptosis. Depending on both cisplatin dose and cellular … WebWe have treated four prostate tumor cell lines, DU-145, PC-3, LNCaP and 22RV1 with various concentrations of cisplatin in order to check for influence on viability and for onset of apoptosis induction. At a cisplatin concentration of 20 microM, 22RV1 and DU-145 cells showed approximately 22% and 18% … side effects of sabudanaWebJan 6, 2024 · Cisplatin is a mainstay of systemic therapy for a variety of cancers, such as lung cancer, head and neck cancer, and ovarian cancer. However, resistance to cisplatin represents one of the most significant barriers for patient outcome improvement. side effects of saline enema

"WebOct 13, 2024 · Stress responses, including autophagy, cell-cycle arrest, senescence, apoptosis, programmed necrosis and inflammation have key roles in the pathogenesis … " - Cisplatin and apoptosis

Cisplatin and apoptosis

Cisplatin-induced peripheral neuropathy is associated with …

WebOct 5, 2014 · Because cisplatin is a DNA-damaging agent and an inducer of apoptosis, it is reasonable to expect changes in HSPs in the development of cellular resistance … WebMar 9, 2024 · The pathophysiology of cisplatin-induced AKI involves proximal tubular injury, apoptosis, oxidative stress, inflammation, and vascular injury in the kidneys. At present, there are no effective drugs or methods for cisplatin-induced kidney injury.

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WebJan 30, 2024 · While apoptosis activation pathways were not observed in DRG sensory neurons of cisplatin-treated mice, these neurons did express several senescence hallmarks, including senescence-associated β-galactosidase, phospho-H2AX, and nuclear factor kappa B (Nfkb)-p65 proteins. WebAug 6, 2015 · It has been reported that cisplatin induces the expression of p53, which plays diverse roles, particularly in regulating glycolysis genes [ 8 – 11 ]. Down-regulation of glycolysis genes when p53 is over-expressed leads to apoptosis. Moreover, energy status of cell is the main determining factor in cell survival or cell death.

WebAbstract Cisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. ... adenocarcinoma promotes proliferation via the accumulation of β-catenin 17 and regulates lung tumorigenesis through cell apoptosis and autophagy pathways. 16 USP14 is critical ... WebActivated P13K/Akt/mTOR pathway attenuates the antitumor effects of chemotherapeutics leading to cancer cells survival and its proliferation, 53 which plays a pivotal role in …

WebCisplatin - CAS 15663-27-1, is a platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation. Synonym (s): Cisplatin, CPDC, DDP, cis-Diaminedichloroplatinum Linear Formula: Pt (NH3)2Cl2 CAS Number: 15663-27-1 MDL number: MFCD00011623 NACRES: NA.77

WebCisplatin (cis-diamminedichloroplatinum; CDDP) 1 is a potent inducer of growth arrest and/or apoptosis in most cell types and is among the most effective and widely used chemotherapeutic agents employed for …

WebJan 5, 2016 · In conclusion, NF-κB transcriptional inhibition in cisplatin-induced AKI ameliorates kidney function and ATN without a significant effect on apoptosis and is associated with a decrease pro-inflammatory mediators and CARD11. Keywords: Acute kidney injury; Apoptosis; Cisplatin; NF-κB; Necrosis. Copyright © 2015. Published by … side effects of salbutamol inhalerWebDec 12, 2024 · Cisplatin-induced AKI is characterised by increased apoptosis of renal tubular epithelial cells, and the results of the present study demonstrated that PSTPIP2 … the pizza joint 49th pinellas parkWebThe cardiotoxic effect of chemotherapeutic agents as cisplatin has become a major issue recently. Interference with mitochondrial dynamics, biogenesis, redox status, and apoptosis are the most possible underlying mechanisms. Semaglutide is a human glucagon-like peptide-1 receptor agonist (GLP-1R), w … side effects of saffron supplementsWebSep 5, 2011 · Bcl-2 blocks cisplatin-induced apoptosis and predicts poor outcome following chemoradiation treatment in advanced oropharyngeal squamous cell carcinoma. Clin Cancer Res 15: 1645–1654. the pizza joint fl pinellas parkWebNational Center for Biotechnology Information the pizza hutWebDec 17, 2024 · In cisplatin-induced acute kidney injury (AKI) or nephrotoxicity, autophagy is rapidly induced in renal tubular epithelial cells and acts as a cytoprotective mechanism for cell survival. Both mTOR and AMPK have been implicated in the regulation of autophagy in cisplatin-induced AKI. the pizza hut logoWebTo further confirm that CYP1B1 is the executor of the UCA1/miR-513a-3p/CYP1B1 molecular axis regulating GC cell apoptosis induced by cisplatin, we simultaneously … the pizza joint allentown pa reviews