Computational studies of lipid droplets
WebJul 28, 2011 · Author Summary Lipid droplets (LD) are primary lipid storage structures that also function in membrane and lipid trafficking, protein turnover, and the reproduction of deadly viruses. Increased LD accumulation in liver, skeletal muscle, and adipose tissue is a hallmark of the metabolic syndrome. Enlarged LDs are often found in these tissues under … WebOct 17, 2024 · This article reviews CRS imaging and computational image processing techniques for non-destructive profiling of dynamic changes in lipid composition and spatial distribution at the single-cell level. As quantitative CRS imaging progresses synergistically with microfluidic and microscopic platforms for single-cell genomic analysis, we anticipate ...
Computational studies of lipid droplets
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WebComputational Studies of Lipid Droplets Author: Siyoung Kim, Jessica M. J. Swanson, Gregory A. Voth Source: Journal of physical chemistry 2024 v ... Lipid droplets (LDs) are intracellular organelles whose primary function is energy storage. Known to emerge from the endoplasmic reticulum (ER) bilayer, LDs have a unique structure with a core ... WebFeb 1, 2024 · Cancer is the second most common cause of death worldwide, having its origin in the abnormal growth of cells. Available chemotherapeutics still present major …
WebThe dynamic of lipid droplets (LDs), during the differentiation process from fibroblast-like cells into adipocyte, is strictly related to the lipid storage in cells. The number and size of the LDs depends on the lipidic or lipolytic stimulations to which the cells are exposed. Method:
WebJan 1, 2024 · Lipid droplets (LDs) are cellular dynamic structures spanning in size from few to 100 µm in white adipocytes [1]. Their number and size is related to the cellular requests [2], [3], [4]. Their size distribution is a powerful tool useful to describe the differentiation of LDs in mature adipocyte and fibroblast like cells [5]. WebApr 9, 2024 · Obesity results from the expansion of adipose tissue, a versatile tissue regulating energy homeostasis, adipokine secretion, thermogenesis, and inflammation. The primary function of adipocytes is thought to be lipid storage through lipid synthesis, which is presumably intertwined with adipogenesis. However, during prolonged fasting, …
WebOct 1, 2016 · Challenges and issues in computational studies of lipid-poor, discoidal and spheroidal lipoprotein particles. ... In CGMD simulations of lipid droplets containing CE and TG, but no apoA-I, performed by Koivuniemi et al. [133], a similar core lipid distribution to Fig. 13 C-3 was observed but with TG forming a distinct peak near the PL monolayer ...
WebDec 6, 2024 · Recent studies on the biology of lipid droplets have led to new discoveries about their biogenesis and the complexity of their … teks mc watikah pelantikan pengawasWebApr 10, 2024 · The objective of this study was to evaluate the physical stability of five of the most commonly used commercial lipid emulsions: Intralipid 20%, Lipofundin MCT/LCT, Omegaven, SMOFlipid and ClinOleic 20% repacked to polypropylene syringes and stored at 4°C, room temperature (25°C) and 40°C for 30 days. This study is useful in the clinical ... teks mc wisuda madrasahWebMar 10, 2015 · Milk fat globule size is determined by the size of its precursors—intracellular lipid droplets—and is tightly associated with its composition. We examined the relationship between phospholipid composition of mammary epithelial cells and the size of both intracellular and secreted milk fat globules. Primary culture of mammary epithelial cells … teks mc wisuda pondok pesantrenWebA significant percentage (20 to 63%) of patients with NAFLD-related HCC, however, have noncirrhotic and relatively soft tissues (13–20).We hypothesized that lipid droplets … teks mc webinar semi formalWebJun 11, 2024 · To create a specific fluorescent reporter for lipid droplets in zebrafish, we fused tdTomato to the 3’ end of the plin2 cDNA. We chose plin2 because it is a well-known lipid droplet-associated protein that is ubiquitously expressed on lipid droplets across cell types (Olzmann and Carvalho, 2024).We generated stable transgenic zebrafish … teks mc upacara kesaktian pancasilaWebMar 1, 2016 · Here, the authors study the release behavior of lipid nanodiscs from charged nano-droplets in the ESI process using microsecond atomistic molecular dynamics simulations. View Show abstract teks mc wisuda tkWebOct 1, 2024 · Lipid droplets and protein handling LDs have also been implicated in various steps of the life cycle of specific proteins. LDs can assist with proper folding and assembly of higher order complexes and mediate temporary sequestration of proteins from other cellular compartments, with the best studied examples involving nuclear proteins. teks mc wisuda tahfidz