Cytosolic phospholipase
WebMar 12, 2024 · PLA2G4A encodes for the cytosolic phospholipase A2α (cPLA2α), which is the rate-limiting enzyme in phospholipid metabolism and plays an important role during … WebMar 1, 2014 · Here, we show that cytosolic phospholipase A 2 ε (cPLA 2 ε, also known as PLA2G4E) is targeted to the membrane compartments of the clathrin-independent endocytic route through a C-terminal stretch of positively charged amino acids, which allows the enzyme to interact with phosphoinositide lipids [especially PI (4,5)P 2] that are enriched …
Cytosolic phospholipase
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WebCytosolic phospholipase A 2 (cPLA2) is a calcium-dependent enzyme that cleaves fatty acids, such as arachidonic acid, from phospholipids by hydrolyzing the SN-2 acyl bond …
WebCytosolic phospholipase A2 is an enzyme that in humans is encoded by the PLA2G4A gene. [5] [6] Function [ edit] This gene encodes a member of the cytosolic … WebApr 16, 2024 · Calcium-dependent cytosolic phospholipase A 2 (cPLA2) releases arachidonic acid (AA, 20:4 n-6), which plays important functions in storing energy, as a second messenger in neurotransmission, and as the precursor of eicosanoids [ 4, 5 ].
WebMar 7, 2024 · Molecular dynamics simulations revealed the optimal phospholipid binding mode leading to a detailed understanding of the preference of cytosolic phospholipase … WebApr 16, 2024 · Background Apolipoprotein E4 (APOE4) is associated with a greater response to neuroinflammation and the risk of developing late-onset Alzheimer’s disease …
WebApr 20, 1999 · Cytosolic phospholipase A2 initiates the biosynthesis of prostaglandins, leukotrienes, and platelet-activating factor (PAF), mediators of the pathophysiology of asthma and arthritis.
WebCytosolic phospholipase A2, group IVa, (cPLA2, also known as cPLA2a, PLA2G4A) is a member of the PLA2 superfamily that catalyses the cleavage of fatty acids from the sn-2 position of phospholipids. PLA2 isoenzymes vary in their cellular localizations, Ca 2+ sensitivities and substrate specificities. cPLA2 mRNA is widely expressed in tissues and ... the raid redemption مترجمWebThe discovery of the cytosolic phospholipase A 2 has added new insight into the cell signaling events that initiate the ‘arachidonate cascade’ described in Chapter 11. The sequence of the cytosolic phospholipase A 2 has been deduced from the cDNA isolated from a number of species [20]. The enzyme, mapped to chromosome 1, is highly … the raikage fanfictionWebJun 2, 2024 · As the initial enzyme in neuroinflammation, cytosolic phospholipase A2(cPLA2) can hydrolyze membranous phosphatides at the sn-2 position in a preferential way to release lysophospholipids and ω3-polyunsaturated fatty acid dominated by arachidonic acid, thereby inducing secondary injuries. the raikes care homeWebPhospholipase a2 activity. Specific Function. Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. Pfam Domain Function. the raikar case online watchWebMar 13, 2001 · To clarify the role of AA in tumorigenesis, we have examined the effect of deleting the group IV cytosolic phospholipase A 2 (cPLA 2) locus (Pla2g4). We report that Apc Min/+, cPLA 2−/− mice show an 83% reduction in tumor number in the small intestine compared with littermates with genotypes Apc Min/+, cPLA 2+/− and Apc Min/+, cPLA 2+/+. the raid - redenzioneWebMar 28, 2024 · These observations suggest that cytosolic Tli is required for the activation and/or export of Tle. We show that Tle growth inhibition activity remains Tli-dependent when phospholipase delivery into target bacteria is ensured through fusion to the VgrG β-spike protein. Together, these findings indicate that Tli has distinct functions depending ... signs and symptoms of ischemic heart diseaseWebJun 1, 2024 · Primary structure of cytosolic phospholipase A2 (cPLA 2) enzymes. (Adopted from [ 3 ].) Schematic representation of the murine cPLA 2 family. Boxes represent conserved domains within the enzymes. Binding of two Ca 2+ ions to the C2/CaLB domain may cause the translocation of the enzymes to membranes. signs and symptoms of insulin overdose