WebDaptomycin is inactivated by pulmonary surfactant and should not be used in treating infections of the lung (e.g., pneumonia). Phase 3 clinical trials of daptomycin in adults with community-acquired pneumonia showed reduced efficacy and increased rates of serious cardiorespiratory adverse events in patients who received daptomycin. WebThe optimal dosing of daptomycin for treatment of osteomyelitis is uncertain; dosing used …. Acute cellulitis and erysipelas in adults: Treatment. …) Daptomycin 4 to 6 mg/kg IV every 24 hours (alternative) Vancomycin is the preferred option because of extensive experience with this agent. For patients who cannot take vancomycin or ...
Daptomycin-induced eosinophilic pneumonia - a …
WebMay 11, 2024 · Daptomycin – inactivated by the surfactant in the lungs. – DO NOT use daptomycin to treat lung infections. *Remember: L inezolid, L ung (you can use Linezolid for lung infections) Echinocandins (ex. micafungin, caspofungin, anidulafungin) – do not reach therapeutic levels in the urinary tract. – DO NOT use echinocandins to treat ... WebDaptomycin is inactivated by surfactant, yielding relatively low concentrations in bronchial-alveolar epithelial lining fluid and lung parenchyma. 45 Limited pharmacokinetic and clinical data have been reported in children. 46–48 The prolonged half-life allows for … how far is page from phoenix az
Daptomycin (Intravenous Route) Side Effects - Mayo Clinic
WebMar 8, 2024 · Alternative therapy: Instead of vancomycin for left-sided native valve endocarditis caused by MSSA [2] S. aureus and Enterococcus spp. prosthetic joint infections. S. aureus and Enterococcus spp. native vertebral osteomyelitis [9] Note: daptomycin should not be used for the treatment of pneumonia. There's more to see -- … WebNational Center for Biotechnology Information WebDO NOT USE FOR PNEUMONIA – it is inactivated by surfactant in the lung; There is a Cubicin RF product of daptomycin that has longer stability and more convenient storage Comparison of Cubicin versus Cubicin RF; … how far is pa from washington state