Dichloromethane mutagenicity

WebJul 1, 2024 · It has been suggested that dichloromethane (DCM) and 1,2-dichloropropane (DCP) are responsible for occupational cholangiocarcinoma. Dihaloalkanes are metabolically activated by GSH S-transferase theta1 (GSTT1) to yield products such as episulfonium ions. However, whether the GSTT1-mediated step of t … WebSix chicken-essence concentrates (CEC) or their dichloromethane extracts (DECE) showed inhibition of the mutagenicity of indirect environmental mutagens such as 2-amino-3-methylimidazo[4,5- f]quinoline (IQ), 3-amino-l-methyl-5-H-pyrido[4,3-b] indole (Trp-P-2), and benzo[a]pyrene (B[a)P), but contrarily had no effect on direct environmental ...

Enzyme-mediated dichloromethane toxicity and …

WebThe mutagenicity of dichloromethane was evaluated in Salmonella bacterial tester strains TA98, TA100, TA1535, TA1537, and TA1538 and Saccharomyces cerevisiae yeast … WebProduct name : Dichloromethane Product Number : 270997 Brand : Sigma-Aldrich Supplier : Sigma-Aldrich 3050 Spruce Street SAINT LOUIS MO 63103 USA Telephone : +1 800-325-5832 ... Germ cell mutagenicity Genotoxicity in vivo - rat - Oral DNA damage Carcinogenicity Carcinogenicity - rat - Inhalation Tumorigenic:Carcinogenic by RTECS … green plain background https://makingmathsmagic.com

The role of glutathione in the bacterial mutagenicity of vapour …

Webfor mutagenicity of a cosmetic substance to be annexed in the Regulation (EC) No 1223/2009 should include tests to provide information on the three genotoxic endpoints, namely 1) mutagenicity at the gene level, 2) chromosome breakage and/or rearrangements (clastogenicity), and 3) numerical chromosome aberrations (aneuploidy). This WebEnzyme-mediated dichloromethane toxicity and mutagenicity of bacterial and mammalian dichloromethane-active glutathione S-transferases. The kinetic properties of bacterial … WebSep 1, 1983 · The metabolic activation and mutagenicity of dichloromethane and chlorofluoromethane were investigated using rat liver fractions and Salmonella typhimurium strain TA100. Both dihalomethanes gave a mutagenic response without the addition of rat-liver fractions. This response has been shown to be due to bacterial metabolism of the … greenplain road norfolk

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Dichloromethane mutagenicity

Mutagenicity - an overview ScienceDirect Topics

http://www.feql.wsu.edu/MSDS/Dichloromethane.pdf Webfor mutagenicity of a cosmetic substance to be annexed in the Regulation (EC) No 1223/2009 should include tests to provide information on the three genotoxic endpoints, …

Dichloromethane mutagenicity

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WebNov 28, 2016 · 1,2-Dichloropropane (1,2-DCP) and dichloromethane (DCM) are possible causative agents associated with the development of cholangiocarcinoma in employees … WebGerm cell mutagenicity Ames test S. typhimurium Result: negative Mutagenicity (micronucleus test) Hamster - male and female Result: negative Carcinogenicity IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity No …

WebThe kinetic properties of bacterial and rat liver glutathione S-transferases (GST) active with dichloromethane (DCM) were compared. The theta class glutathione S-transferase (rGSTT1-1) from rat liver had an affinity for dihalomethanes lower by three orders of magnitude (K app > 50 mM) than the bacterial DCM dehalogenase/GST from … WebDichloromethane is no longer produced in Canada (CPI, 2000). From 1977 to 1990, the quantity of dichloromethane imported and used in Canada ranged annually from 9 to 13.2 kilotonnes (Environment Canada, 1990); however, usage of pure dichloromethane, recycled dichloromethane and dichloromethane contained in formulations has …

WebDichloromethane, Methylene dichloride CAS No. 75-09-2 RTECS No. PA8050000. DOT ID & Guide. 1593 160. Formula. CH₂Cl₂ ... WebAgency for Toxic Substances and Disease Registry

WebMutagenicity is an important toxicological endpoint that requires thorough evaluation during the industrial chemical registration process. Regulatory requirements for mutagenicity assessment in registration of industrial chemicals vary in geographic regions (and in some cases by intended application). ... Methanol (90%) and dichloromethane ...

WebAug 15, 1983 · Four dihalomethanes; dichloromethane, bromochloromethane, dibromomethane and diiodomethane, have been studied with respect to their reactivities … green plaid wrapping paperWebU.S EPA Web Server green plaid shirt for menWebDichloromethane is a lipophilic solvent of low relative molecular mass, which can readily cross biological membranes. Pulmonary uptake is rapid, approaching steady state within … green plain background imageWebThe dichloromethane extracts of SRM 1649 and SRM 1650 contained direct-acting mutagens in Salmonella strains TA98 and TA100; SRM 1650 was significantly more potent than SRM 1649 in either strain. Addition of S9 caused a large decrease in mutagenicity of each extract, although SRM 1650 remained more potent. green plains cattle company kismet ksWebDichloromethane (DCM) is a colorless liquid with a sweet, pleasant odor. The major use of DCM is as a solvent in the pharmaceutical and chemical industry for reactions, purification and isolation of intermediates or products. green plains cattle company ksWebIn vivo mutagenicity was analyzed by gpt mutation/Spi-assays in the livers of rats. In addition, gene and protein expression of CYP2E1 and GSTT1, the major enzymes … fly sweat outfitsWebDichloromethane (DCM) vapour by inhalation is carcinogenic to rodents and is an in vivo rodent cell clastogen and a bacterial mutagen. It has been suggested that the bacterial mutagenicity of DCM is mediated by glutathione (GSH) conjugation. The involvement of endogenous and exogenous GSH in the con … fly swat zapper