Irisin ferroptosis
WebJan 15, 2024 · Irisin serves as a novel approach to eliciting cardioprotection, which is associated with the improvement of mitochondrial function and significantly attenuated hypoxia/reoxygenation (H/R), as indicated by the reduction of lactate dehydrogenase (LDH) leakage and apoptotic cardiomyocytes. 99 PDF View 1 excerpt, references background WebOct 28, 2024 · Ferroptosis was clearly defined in 2012 as a newly discovered iron-dependent, peroxide-driven, nonapoptotic form of regulated cell death. Ferroptosis is considered the cause of reperfusion injury. This discovery provides new avenues for the recognition and treatment of diseases.
Irisin ferroptosis
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WebJun 13, 2024 · Ferroptosis is involved in the ischemia–reperfusion injury (IRI) during LT with a severe steatotic donor liver and HM-exos treatment attenuated graft IRI, which might be a promising strategy to treat IRI in Steatotic grafts. 12 PDF View 1 excerpt, cites background WebSep 1, 2024 · The effect of irisin on ferroptosis was confirmed in LPS-treated hepatocytes and CLP-induced septic mice. Inhibition of glutathione peroxidase 4 (GPX4), a central …
WebAug 5, 2024 · Irisin Is a Positive Regulator for Ferroptosis in Pancreatic Cancer Regulated cell death by way of ferroptosis involves iron-dependent accumulation of cellular reactive …
WebJul 1, 2024 · Ferroptosis is involved in the pathological process of SAE. • Irisin suppressed neurons ferroptosis via Nrf2 pathway. • Irisin ameliorates SAE-induced inflammatory microenvironment through inhibiting hippocampus ferroptosis. • Irisin could attenuate cognitive dysfunction of SAE via ferroptosis resistance. Abstract WebMay 12, 2024 · Ferroptosis is a type of regulated necrosis that is triggered by a combination of iron toxicity, lipid peroxidation, and plasma membrane damage. The upstream inducers of ferroptosis can be divided into two categories (biological versus chemical) and activate two major pathways (the extrinsic/transporter versus the intrinsic/enzymatic pathways).
WebSep 1, 2024 · Irisin is a novel exercise-induced myokine involved in the regulation of adipose browning and thermogenesis. This study is designed to verify the existence of ferroptosis …
WebDec 1, 2024 · Zhang et al. found that irisin reduced ROS level, iron content, MDA level, increased GSH level in mice, and adjusted the expression of GPX4 and ACSL4 to reduce ferroptosis. In the process of the study, irisin also inhibited ROS accumulation and iron content increase in HK-2 cells. And improve the function of mitochondria [51]. derhy sion strasbourgWebSep 17, 2024 · Intriguingly, Yang et al. found that irisin was a positive regulator of ferroptosis. Irisin decreased GXP4 expression and upregulated ROS production to … deriancho cabinet makerWebMar 16, 2024 · "hidden message from v3 (new repo)" Frontiers Impact Metrics Powered by Impact Metrics Powered by chronic rectal inflammationWebMar 17, 2024 · Irisin Mitigates Ferroptosis and Mitochondria Dysfunction in LPS-Induced HK2 Cells. Based on the aforementioned findings in vivo, we next evaluated the function … chronic rectal polyneuropathy icd 10WebFerroptosis is an iron-dependent programmed cell death (PCD), which is distinct from other types of cell death such as apoptosis, necrosis, pyrosis, and autophagy ( Dixon et al., 2012 … chronic reactive arthritis radiologyWebSep 25, 2024 · We observed that irisin can augment ferroptosis-associated increases in free iron concentrations, lipid peroxide levels, and GSH depletion, while increasing the pancreatic cancer cell death rate. chronic recurrent dermatosis with silveryWebMay 25, 2024 · Ferroptosis is an iron-dependent, nonapoptotic cell death method characterized by abnormal accumulation of lipid hydroperoxide and related lipophilic reactive oxygen species (ROS) in the cell membrane [ 7, … chronic rectal pain