Phosphopyruvate hydratase complex
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Phosphopyruvate hydratase, usually known as enolase, is a metalloenzyme (EC 4.2.1.11) that catalyses the conversion of 2-phosphoglycerate (2-PG) to phosphoenolpyruvate (PEP), the ninth and penultimate step of glycolysis. The chemical reaction is: 2-phospho-D-glycerate See more In humans there are three subunits of enolase, α, β, and γ, each encoded by a separate gene that can combine to form five different isoenzymes: αα, αβ, αγ, ββ, and γγ. Three of these isoenzymes (all homodimers) are … See more Using isotopic probes, the overall mechanism for converting 2-PG to PEP is proposed to be an E1cB elimination reaction involving a carbanion intermediate. The following detailed mechanism is based on studies of crystal structure and See more Small-molecule inhibitors of enolase have been synthesized as chemical probes (substrate-analogues) of the catalytic mechanism of the enzyme and more recently, have been investigated as potential treatments for cancer and infectious diseases. … See more Enolase is a member of the large enolase superfamily. It has a molecular weight of 82,000-100,000 Daltons depending on the isoform. In human alpha enolase, the two subunits are See more In recent medical experiments, enolase concentrations have been sampled in an attempt to diagnose certain conditions and their severity. For example, higher concentrations of … See more • Holt A, Wold F (December 1961). "The isolation and characterization of rabbit muscle enolase". The Journal of Biological Chemistry. 236 (12): … See more • Enolase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more WebIdentification; HMDB Protein ID: HMDBP13254: Secondary Accession Numbers: None: Name: Enolase: Synonyms: 2-phospho-D-glycerate hydro-lyase; 2-phosphoglycerate dehydratase
Phosphopyruvate hydratase complex
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WebApr 28, 2014 · In vitro co-immunoprecipitation studies in prostate cancer cell extracts demonstrated that these compounds disrupted the HIF-1α/p300 complex. The downstream effects of inhibiting the HIF-1α/p300 interaction were evaluated by determining HIF-1α target gene expression at the mRNA and protein levels.
WebQuantitative metabolomics services for biomarker discovery and validation. Specializing in ready to use metabolomics kits. Your source for quantitative metabolomics technologies and bioinformatics. WebPredicted to enable phosphopyruvate hydratase activity. Predicted to be involved in glycolytic process. ... Predicted to be part of phosphopyruvate hydratase complex. Orthologous to human ENO4 (enolase 4). Genome Resources. Alliance ; Gene:558487 ; VEGA:OTTDARG00000038661 ; Ensembl(GRCz11):ENSDARG00000070598 ; Note None …
Webphosphopyruvate hydratase complex. Ontology. cellular_component. Synonyms. enolase complex. Alternate IDs. None. Definition. A multimeric enzyme complex, usually a dimer … http://amigo.geneontology.org/amigo/term/GO:0000015
WebOct 25, 2024 · The upper fraction without viral dsRNA in both strains increased the GagPol amount and downregulated a phosphopyruvate hydratase Eno1 and regulator of the Fps1 glycerol channel Ask10. 3.6. STRINGAnalysis. Differentially expressed proteins, ... Molecular complex detection (MCODE) clustering algorithm located four hubs of highly …
WebLiterature; Reviews; News; Aging human genes; Digital aging atlas; Aging cell; Age induced pathology; homosapiens; Age induced physiological changes; Age induced psychological changes dashawn editingWebJul 5, 2005 · Phosphopyruvate hydratase; catalyzes the hydrolysis of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; localized to mitochondria and vacuoles View computational annotations Molecular Function Manually Curated enables melatonin binding ( IDA ) dashawn davis hudlWebA hydro-lyase that catalyzes the dehydration of 2-phosphoglycerate to form PHOSPHOENOLPYRUVATE. Several different isoforms of this enzyme exist, each with its … bitcoinstreamWebAug 13, 2024 · eno; phosphopyruvate hydratase cl21457 Location:70 → 525 TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate … bitcoin strategy pdfWebIs identified as an autoantigen in Hashimoto encephalopathy (HE) a rare autoimmune disease associated with Hashimoto thyroiditis (HT). HT is a disorder in which destructive … dashawn farber wrestlingWebLegend. Settings. Analysis dashawn earlyWebPredicted to be part of phosphopyruvate hydratase complex. Is expressed in several structures, including axis; margin; nervous system; neural tube; and trigeminal placode. Human ortholog (s) of this gene implicated in Alzheimer's disease. Orthologous to human ENO1 (enolase 1). Genome Resources Alliance ( 1) Gene:334116 ( 1) dashawn eldridge