WebMar 3, 2010 · Stat5- but not Stat3-deletion blocks cell proliferation and induces apoptosis in vitro. A, B.. ... Thus, it is conceivable that Stat proteins may also be targeted by low molecular weight compounds that target the dimeric interphase or interaction sites with specific protein partners. WebMay 12, 2010 · These results suggested that STAT5 activation could be important in sustaining CD4 + T-cell proliferation in the absence of APCs in vitro but only when CD4 + T-cells had acquired the capacity to express CD80. ... C.J. Small molecular weight inhibitors of stress-activated and mitogen-activated protein kinases. Mini Rev. Med. Chem. 2006, 6, …
ALKS 4230: a novel engineered IL-2 fusion protein with an …
WebStat5 activity is tightly regulated throughout gestation, lactation, and post-lactation. Purified Mouse Anti-Stat5. Clone 89/Stat5. View all Formats ... Target Molecular Weight: 92 kDa Concentration: 250 µg/ml RRID: AB_397590 Storage Buffer: ... WebMar 15, 2000 · Although all cell lines were found to express both forms of STAT5 (STAT5A and STAT5B), incubation with doxycycline induced the truncated form of STAT5 (estimated molecular weight, 78 kd) in 3 clones of Ba/F3p210ΔSTAT5 (lower panel). No induction of ΔSTAT5 protein was found in Ba/F3p210Ctrl cells. datasheet push button 4 pin
STAT5 - an overview ScienceDirect Topics
WebApr 2, 2024 · STAT5 Inhibitor is a cell-permeable, nonpetidic nicotinoyl hydrazone that specifically suppresses STAT5 (IC₅₀ = 47 µM) via binding to its SH2 domain. It shows reduced potency towards the SH2 domains of STAT1, STAT3, or LCK (Müller et al.). IMMUNOLOGY · Induces partial apoptosis of mature eosinophils at high concentrations … WebNov 17, 2024 · Knocking out STAT5 during the first 3 days of lactation affects the expression of ER and connexin 32 (C × 32, a gap junction protein). STAT5 knockout during the first 10 days of lactation decreases neonatal body weight by 30–40% due to changes in mammary gland morphology and a reduction in milk production. WebIn addition to Stat5 signal attenuation by phosphatase actions or classical feedback inhibition, truncated forms of Stat5 lacking in transactivation capacity may compete … datasheet pxls8974cfr1